摘要：目的  探讨幽门螺杆菌感染与胃癌发生的相关性，为胃癌的临床防治提供参考。方法  选取医院收治的100例胃癌患者为胃癌组和100例非胃癌上消化道疾病患者为非胃癌组，回顾性分析两组患者的13Ｃ呼气试验结果和胃镜病理活检结果，探讨幽门螺杆菌感染与胃癌发生的相关性，胃癌诊断标准符合卫生部发布的《胃癌诊断标准》，采用统计软件SPSS17.0进行数据处理。结果  胃癌组患者13C呼气试验检查幽门螺杆菌感染阳性78例，阳性率为78.0%，高于非胃癌组的45.0%；胃癌组患者胃镜检查幽门螺杆菌感染阳性67例，阳性率为67.0%，高于非胃癌组的34.0%，比较差异均有统计学意义（P＜0.05）；胃癌组和非胃癌组13C呼气试验检查幽门螺杆菌感染阳性率均高于胃镜检查，但比较差异均无统计学意义。结论  胃癌及胃黏膜癌前病变的发生与幽门螺杆菌感染存在一定关系，13C呼气试验可作为幽门螺杆菌感染的筛查方法，早起发现幽门螺杆菌并根治，有助于防止胃癌的发生。
 

Abstract: OBJECTIVE To analyze the correlational of gastric carcinoma and Helicobacter pylori infection, so as to provide reference for clinical prevention and treatment of the gastric cancer. METHODS A total of 100 cases of patients with the gastric carcinoma were selected as the research objects of gastric carcinoma group, and 100 cases of patients with the upper gastrointestinal non tumor diseases were selected as the non gastric carcinoma group. The carbon 13 breath test results and gastroscope pathological biopsy results of the two groups were retrospectively analyzed, and the correlational of gastric carcinoma and helicobacter pylori infection was analyzed. The diagnosis standard of gastric carcinoma was based on the Diagnosis Standard of Gastric Carcinoma published by ministry of health. SPSS 17.0 software was used for data analysis. RESULTS By the carbon 13 breath test, the H. pylori infection positive patients of the gastric carcinoma group was 78 cases, accounting for 78.0%, which was higher than that of the non-gastric carcinoma group which was 45.0%, and the difference was significant (P<0.05). By the gastroscopy, the H. pylori infection positive patients of the gastric carcinoma group was 67 case, accounting for 67.0%, which was higher than that of the non-gastric carcinoma group which was 34.0%, the difference was significant (P<0.05). The H. pylori infection positive rate of the gastric carcinoma group and the non-gastric carcinoma group by the carbon 13 breath test were higher than that by the gastroscopy, the difference was not significant. CONCLUSION Gastric carcinoma and cardiac area mucosa precancerous lesions has certain relation with the occurrence of H. pylori infection. The carbon 13 breath test can be used as a screening method for H. pylori infection. Early found for H. pylori and radical cure for it could help to prevent the occurrence of gastric cancer.