【摘要 】目的：对慢性胃炎儿童患者13C-尿素呼气试 验（13C-UBT）和胃黏膜活体组织检查（活检）Hp两种检测方法进行比较分析。方  法：选取我院收治的慢性胃炎儿童患者46例，分别进行13C-尿素呼气试验检测和胃黏膜活检Hp检测，并以胃黏膜活检Hp检测结果为标准，比较13C-对幽门螺旋杆菌检出的准确度、特异性和敏感度，并对检测出Hp阳性患者采用质子泵抑制剂（PPI）进行治疗，观察其临床疗效。结果：胃黏膜活检Hp检测结果显示，13C-的准确度、特异性和敏感度分别为97.83%、92.86%和100%，且对Hp阳性患者采用PPI三联疗法治疗的转阴率要显著优于采用单纯PPI和PPI二联疗法的患者，差异有统计学意义（P-0.05）。结论：与胃黏膜活检Hp方法相比，13C-UBT方法在Hp的检出上具有较高的准确度、特异性和敏感度，同时操作简单、对人体无害和非侵入性等优点，是儿童感染慢性胃炎的理想诊断方法，值得在儿科推广和应用。

【ABSTRACT】 Objective: To children chronic gastritis patients 13 c-UBT and gastric mucosal biopsies Hp two kinds of detection methods comparative analysis. Methods: The patients of chronic gastritis, 46 cases of children were 13 c-urea breath test and gastric mucosal biopsies Hp testing more 13 c-UBT for helicobacter pylori detection accuracy, specificity and sensitivity. And the detection of Hp positive patients treated by PPI and to observe its efficacy. Results: The gastric mucosal biopsies Hp testing results showed that 13 c-UBT accuracy, specificity and sensitivity were 97.83%, 92.86% and 100% and the PPI triple therapy, shade rate was superior to pure PPI and PPI duplex therapy, significant difference (P.0.05). Conclusion: And gastric mucosal biopsy method than Hp. 13 c-UBT method in Hp’s detection has higher accuracy, specificity and sensitivity, and at the same time, the operation is simple, harmless to the human body and noninvasive etc.