【摘要】目的  探讨血清中胃蛋白酶原（PG I、PGII）含量及其比值（PGR)，在胃癌诊断中的意义。方法  采用时间分辨荧光免疫分析法 (TRFIA)，检测198例正常对照者、89例胃溃疡患者及67例胃癌患者血清中的PG I、PGII含量并计算PGR。结果  胃溃疡患者PG I、 PGII较正常对照组明显升高，差异具有显著性（P<0.05)，PGR差异无显著性（P>0.05)；胃癌患者PG I、PGR较正常对照组显著降低， 差异显著（P<0.0l)， PGII差异无显著性（P>0.05)。结论  测定血清PGI、PGII水平及PGR值对胃癌的早期筛查及鉴别诊断有临床意义。关键词:胃蛋白酶原；胃溃疡；胃癌

中图分类号：R735.2    文献标识码：B        文章编号：1671-8194 (2014) 23-0048-02

[Abstract] Objective The objective of this study was to explore the significance of serum pepsinogen I and II (PG I，PG D) content and its ratio (PGR) in the diagnosis of gastric cancer. Methods We use time-resolved fluorescence immunoassay (TRFIA) to test serum pepsinogen I and H (PG I ， PG D) content and its ratio (PGR) in 198 cases of normal controls， 89 patients with gastric ulcer and 89 cases of gastric cancer patients. Results The content of PG I ， PG II in Patients with gastric ulcer was obviously higher than normal control group， with significant difference (P<0.05)， PGR had no significant difference (P>0.05)； PG I， PGR in gastric cancer patients significantly reduced compared with normal control group， with significant difference (P<0.0l)； PG n had no significant difference (P>0.05) between the two groups. Conclusion We conclude that serum pepsinogen I and II (PG I ， PG II) content and its ratio (PGR) in the diagnosis of gastric cancer has important clinical significance.

[Key words] Propepsin； Gastric ulcer； Gastric carcinoma