中华肾病研究电子杂志 2014 年 4 月第 3 卷第 2 期 Chin J Kidney Dis Invest ( Electronic Edition )，April 2014, Vol.3，No.2    • 73 •

幽门螺杆菌感染与IgA肾病的发生与发展

【摘要】IgA肾病是全球范围内最为常见的原发性肾小球疾病，目前公认其是一种免疫介导性 炎症疾病，但具体发病机制尚不清楚。幽门螺杆菌（Hp)是一种定植于人类胃肠道的微需氧革兰阴性 菌，幽门螺杆菌感染能引起急慢性的炎症免疫反应。近年来研究发现Hp感染与IgA肾病之间存在一 定的联系，Hp可能是IgA肾病的潜在致病原之一。相关研究已成为目前学术界的热点。该文结合国 内外和四川大学生物治疗国家重点实验室团队的研究，就HP感染与IgA肾病的发生发展机制进行 了论述。
【关键词】幽门螺杆茵；IgA肾病；致病机制
Helicobacter pylori infection and the development and progression of IgA nephropathy Ma Xin，
Fan Junming. Department of Nephrology，Affiliated Hospital of Luzhou Medical College，Lmhou 646000; Sichuan University West China Hospital，State Key Laboratory of Biotherapy，Chengdu 610000，Sichuan Province, China
Corresponding author: Fan Junming，Email: junmingfan@ 163. com
【Abstract 】    IgA nephropathy is the most common primary glomerulai，disease worldwide which is
recognized as a kind of immune-mediated inflammatory disease although its pathogenesis is not clear yet. Helicobacter pylori ( Hp ) is a kind of microaerobic gram-negative bacterium colonized in human gastrointestinal tract. Hp infection can cause acute or chronic immune inflammation. In recent years，it has been found that there is a certain relationship between Hp infection and IgA nephropathy，and that Hp is likely to be one of the potential pathogenic agents of IgA nephropathy，and related research has become a hot spot of acade ia. hether p infection is associated ith the develop ent and progression of Ig nephropathy has become a hot spot of research. This review will discuss HP infection and pathological mechanism of IgA nephropathy，synthesizing domestic and international results including our own.
【Key word 】Helicobacter pylori;    IgA nephropathy; Pathogenesis