【摘要】 IgA肾病是全球范围内最为常见的原发性肾小球疾病，目前公认其是一种免疫介导性炎症疾病，但具体发病机制尚不清楚。幽门螺杆菌（Hp）是一种定植于人类胃肠道的微需氧革兰阴性菌，幽门螺杆菌感染能引起急慢性的炎症免疫反应。近年来研究发现Hp感染与IgA肾病之间存在一定的联系，Hp可能是IgA肾病的潜在致病原之一。相关研究已成为目前学术界的热点。该文结合国内外和四川大学生物治疗国家重点实验室团队的研究，就HP感染与IgA肾病的发生发展机制进行了论述。

【Abstract】  IgA nephropathy is the most common primary glomerular disease worldwide which is recognized as a kind of immune-mediated inflammatory disease although its pathogenesis is not clear yet. Helicobacter pylori (Hp) is a kind of microaerobic gram-negative bacterium colonized in human gastrointestinal tract. Hp infection can cause acute or chronic immune inflammation. In recent years，it has been found that there is a certain relationship between Hp infection and IgA nephropathy, and that Hp is likely to be one of the potential pathogenic agents of IgA nephropathy，and related research has become a hot spot of academia. Whether Hp infection is associated with the development and progression of IgA nephropathy has become a hot spot of research. This review will discuss HP infection and pathological mechanism of IgA nephropathy, synthesizing domestic and international results including our own.