【摘要】目的  检测幽门螺杆菌(Helicobacter pylori Hp)的方法很多，本文对病理组织学，血清学，快速尿素酶和13C呼气试验进行分析评价。方法  对70例有消化道症状的忠者进行以上四种方法检测幽门螺杆菌，其中二项阳性者认为有Hp感染。结果  病理组织学, 血清学，13C呼气试验，快速尿素酶检测的敏感性分别为83.33 % , 90.74%，96.30% , 85.52%；特异性分别为100% , 100% , 81.25% , 75%。四种方法的阳性预测值分别为100% , 100%, 94.55 % , 92% ;阴性预测值分别为64%,76.19%,86.67%,60%。结论  病理组织学与呼气试验是检测Hp感染的较准确的测定方法，呼气试验更能反映“全胃”Hp感染状况，目前可作为抗Hp药物疗效监测的“金标准”。血清学检测和快速尿素酶法操作方便，费用低，是临床常用的检测手段。

[Abstrct]Objective The aim of this study is to evaluate the four methods of detecting Hp infection is histology, serology (HM-CAP)“C urea breath test (UBT)and rapid urease test(RUT). Methods seventy patients with symptoms of epigastric pain and dyspepsia underwent endoscopy and biopsy of gastric antrum. The biopsied specimens were stained with haematoxylin and eosin(HE), and tested by rapid urease tests(RUT). Serology was performed by EIA, using High  MolecularWeight Cell-Associated Protein(HM CAP) and "C urea breath test(UBT) were tested in all patients. The presence of two positives were indication of presence of Hp infection. Results The sensitivities were: histology 83.33%， "C UBT 90.74%，serology 96.30% ,RUT 85.52%; the specificities were: histology 100%，"C UBT 100%，serology 81.25%,RUT 75%. The positive predictive values were:100%，100%, 94.55%, 92.00%; and the neagtive predictive values were: 64%，76.19% ,86.67%，60%. Conclusions Histology and "C UBT are the two more sensitive and more accurate methods for detecting Hp infection. "C UBT is noninvasive which reflects the infectious status of the whole stomach and can be used as " gold standard" for the evaluation of Hp eradication. Serology and RUT are simple to perform, cost- effective and good for screening.