摘要：目的  观察冠心病患者幽门螺杆菌（Hp）感染，探讨Hp对血清炎症因子的影响，为了解Hp在冠心病中的作用提供依据｡方法  2013年1月-2014年1月，检测152例冠心病患者（冠心病组）和90名健康对照者（对照组）幽门螺杆菌､热休克蛋白60（HSP60）､白细胞介素-18（IL-18）､可溶性血管细胞黏附分子-1（sVCAM-1）､超敏C - 反应蛋白（hsCRP）水平，并采用logistic回归分析冠心病的影响因素｡结果  冠心病组患者Hp阳性率为53.3%､对照组为21.1%，冠心病组患者血清 HSP60､IL-18､VCAM-1和hsCRP水平均明显高于对照组，差异有统计学意义（P<0.05）；冠心病Hp感染阳性组患者血清HSP60､IL-18､VCAM-1和hsCRP水平明显高于Hp阴性组，差异有统计学意义（P <0.05）｡结论  Hp感染与冠心病的发生存在密切关系，其可能通过刺激炎性因子的释放参与了冠心病的发生发展｡

Abstract: OBJECTIVE To observe the Helicobacter pylori infection in the patients with coronary heart disease and explore the influence of the H. pylori on the serum inflammatory cytokines so as to define the role of the H. pylori in the coronary heart disease. METHODS From Jan 2013to Jan 2014, totally 152patients with coronary heart disease (the coronary heart disease group) and 90healthy people (the control group) were enrolled in the study, then the H. pylori and the levels of heat shock protein 60 (HSP60), interleukin-18 (IL-18), soluble vascular cell adhesion molecule-1 (sVCAM-1), and high-sensitivity C-reactive protein (hsCRP) were determined; the logistic regression analysis was performed for the influencing  factors for the coronary  heart disease. RESULTS The positive rate of H. pylori was 53.3%in the coronary heart disease group, 21.1% in the control group. The levels of the serum HSP60, IL-18, VCAM-1, and hsCRP of the coronary heart disease group were significantly higher than those of the control group (P <0.05). The levels of the serum HSP60, IL-18, VCAM-1, and hsCRP of the coronary heart disease patients positive for H. pylori infection were significantly higher than those of the coronary heart disease patients negative for the H. pylori (P<0.05). CONCLUSION The H. pylori infection is closely associated with the incidence of coronary heart disease, which may involve in development of coronary heart disease by stimulating the release of inflammatory cytokines.