摘要：目的探讨血清胃蛋白酶原(PG)检测诊断消化性溃瘍（PU)的临床价值。方法采用时间分辨荧光免疫分析法检测98例I>U患者和52例健康者的血清PGI、PGII和PGI/PGII，并进行比较。结果与健康者比较，PU患者血清PGI、PGII升高（P<0.01)，PGI/PGII无明显变化(P>0.05)。以受试者工作特征曲线分析PGI、PGII对DU的诊断价值，曲线下面积分别为0.79、0.72；PGI 205ng/ml为其最佳诊断阈值，其灵敏度54.1%，特异度94.2%；PGII17.5ng/ml为其最佳诊断阈值，其灵敏度37.8%，特异度92.3%。结论  血清PGI、PGII升高提示患PU的风险增加，PG检测在PU筛查及诊断中均有临床意义，PGI可作为经济实用的PU筛查指标。
关键词：消化性溃疡；胃蛋白酶原；时间分辨荧光免疫分析
中图分类号：R573.1    文献标志码：A 文章编号：1002-266X(2010)374)-0016-02

Abstract： Objective To investigate the clinical value of serum pepsinogen (PG) test in the diagnosis of peptic ulcer (PU) . Method The serum PG I and PG II levels and PG I /PG II ratio were measured by time-resolved fluorescence im¬munoassay (TRFIA) in 98 PU patients and 52 healthy controls， and the results were compared. Results PG I and PG U levels of PU group were higher than those of control group (P<0. 01). PG I /PG II ratio showed no significant difference between two groups ( P > 0. 05). Receiver operating characteristic curve analysis was used to assess the performance of ser¬um PG I and PG II levels in diagnosis of PU. The area under the curve of PG I and PG II was 0. 79 and 0.72， respective¬ly. The optimal cut-off value of 205 ng/ml for PG I yielded a sensitivity of 54. 1 % and a specificity of 94.2% ， while the optimal cut-off value of 17. 5 ng/ml for PG II yielded a sensitivity of 37. 8% and a specificity of 92. 3%. Conclusion In¬creased serum PG I and PG E levels indicate a higher risk of peptic ulcer. Serum PG test is a useful method for PU screening and diagnosis. PG I could be considered as an economic marker for PU screening.
Key words： peptic ulcer； pepsinogen； time resolved fluorescence immunoassay